Comparative study of the efficacy of herbal antioxdants oxitard and aloe vera in the treatment of oral submucous fibrosis
Identifieur interne : 003037 ( Pmc/Curation ); précédent : 003036; suivant : 003038Comparative study of the efficacy of herbal antioxdants oxitard and aloe vera in the treatment of oral submucous fibrosis
Auteurs : Santosh Patil ; Vishal Halgatti ; Sneha Maheshwari [Inde] ; B S. SantoshSource :
- Journal of Clinical and Experimental Dentistry [ 1989-5488 ] ; 2014.
Abstract
Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder predominantly seen in the Indian subcontinent due to areca nut, tobacco and their products. The aim of the present study was to compare the efficacy of oxitard and aloe vera in the management of OSMF. Material and Methods: 120 subjects with OSMF were included in the study. The patients were clinico-pathologically diagnosed and divided equally in 2 groups, Group A (oxitard group) and Group B (aloe vera group). Group A was administered 2 oxitard capsules twice daily and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Different clinical parameters were evaluated at regular intervals. Data was analyzed using the Student’s paired t test and Chi-square test. P-value <0.001 was considered to be statistically significant. Results: Clinical improvements in mouth opening and tongue protrusion was significant in the oxitard group (p=0.0005). Subjective symptoms of pain associated with the lesion (p=0.0003), difficulty in swallowing (p=0.0000) and speech (p=0.0001) also significantly improved in the Group A. The improvement in burning sensation was not statistically significant between the 2 groups (p=0.002). There was a mild to moderate decrease in the size of the lesion. Conclusions: Though there is no definitive treatment for the condition however, overall assessment of symptoms like mouth opening, tongue protrusion, difficulty in swallowing and speech and pain associated with the lesion showed that oxitard capsules can bring about significant clinical improvements than aloe vera gel in the treatment of OSMF.
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DOI: 10.4317/jced.51424
PubMed: 25136428
PubMed Central: 4134856
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Santosh Patil<affiliation><nlm:aff id="A1">Reader, Dept of Oral Medicine and Radiology, Chattisgarh Dental College Research Institute, Rajnandgaon, Chattisgarh. India</nlm:aff><wicri:noCountry code="subfield">Chattisgarh. India</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Assistant Professor, Dept of Dentistry, Belgaum Institute of Medical Sciences, Belgaum,Karnataka. India</nlm:aff><wicri:noCountry code="subfield">arnataka. India</wicri:noCountry></affiliation><affiliation><nlm:aff id="A4">Reader, Dept of Oral and Maxillofacial Surgery, Chattisgarh Dental College Research Institute, Rajnandgaon, Chattisgarh. India</nlm:aff><wicri:noCountry code="subfield">Chattisgarh. India</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative study of the efficacy of herbal antioxdants oxitard and aloe vera in the treatment of oral submucous fibrosis</title><author><name sortKey="Patil, Santosh" sort="Patil, Santosh" uniqKey="Patil S" first="Santosh" last="Patil">Santosh Patil</name><affiliation><nlm:aff id="A1">Reader, Dept of Oral Medicine and Radiology, Chattisgarh Dental College Research Institute, Rajnandgaon, Chattisgarh. India</nlm:aff><wicri:noCountry code="subfield">Chattisgarh. India</wicri:noCountry></affiliation></author><author><name sortKey="Halgatti, Vishal" sort="Halgatti, Vishal" uniqKey="Halgatti V" first="Vishal" last="Halgatti">Vishal Halgatti</name><affiliation><nlm:aff id="A2">Assistant Professor, Dept of Dentistry, Belgaum Institute of Medical Sciences, Belgaum,Karnataka. India</nlm:aff><wicri:noCountry code="subfield">arnataka. India</wicri:noCountry></affiliation></author><author><name sortKey="Maheshwari, Sneha" sort="Maheshwari, Sneha" uniqKey="Maheshwari S" first="Sneha" last="Maheshwari">Sneha Maheshwari</name><affiliation wicri:level="1"><nlm:aff id="A3">Dental Practitioner, Jodhpur, Rajasthan, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Dental Practitioner, Jodhpur, Rajasthan</wicri:regionArea></affiliation></author><author><name sortKey="Santosh, B S" sort="Santosh, B S" uniqKey="Santosh B" first="B S." last="Santosh">B S. Santosh</name><affiliation><nlm:aff id="A4">Reader, Dept of Oral and Maxillofacial Surgery, Chattisgarh Dental College Research Institute, Rajnandgaon, Chattisgarh. India</nlm:aff><wicri:noCountry code="subfield">Chattisgarh. India</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25136428</idno><idno type="pmc">4134856</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134856</idno><idno type="RBID">PMC:4134856</idno><idno type="doi">10.4317/jced.51424</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003037</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003037</idno><idno type="wicri:Area/Pmc/Curation">003037</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003037</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative study of the efficacy of herbal antioxdants oxitard and aloe vera in the treatment of oral submucous fibrosis</title><author><name sortKey="Patil, Santosh" sort="Patil, Santosh" uniqKey="Patil S" first="Santosh" last="Patil">Santosh Patil</name><affiliation><nlm:aff id="A1">Reader, Dept of Oral Medicine and Radiology, Chattisgarh Dental College Research Institute, Rajnandgaon, Chattisgarh. India</nlm:aff><wicri:noCountry code="subfield">Chattisgarh. India</wicri:noCountry></affiliation></author><author><name sortKey="Halgatti, Vishal" sort="Halgatti, Vishal" uniqKey="Halgatti V" first="Vishal" last="Halgatti">Vishal Halgatti</name><affiliation><nlm:aff id="A2">Assistant Professor, Dept of Dentistry, Belgaum Institute of Medical Sciences, Belgaum,Karnataka. India</nlm:aff><wicri:noCountry code="subfield">arnataka. India</wicri:noCountry></affiliation></author><author><name sortKey="Maheshwari, Sneha" sort="Maheshwari, Sneha" uniqKey="Maheshwari S" first="Sneha" last="Maheshwari">Sneha Maheshwari</name><affiliation wicri:level="1"><nlm:aff id="A3">Dental Practitioner, Jodhpur, Rajasthan, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Dental Practitioner, Jodhpur, Rajasthan</wicri:regionArea></affiliation></author><author><name sortKey="Santosh, B S" sort="Santosh, B S" uniqKey="Santosh B" first="B S." last="Santosh">B S. Santosh</name><affiliation><nlm:aff id="A4">Reader, Dept of Oral and Maxillofacial Surgery, Chattisgarh Dental College Research Institute, Rajnandgaon, Chattisgarh. India</nlm:aff><wicri:noCountry code="subfield">Chattisgarh. India</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Clinical and Experimental Dentistry</title><idno type="eISSN">1989-5488</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder predominantly seen in the Indian subcontinent due to areca nut, tobacco and their products. The aim of the present study was to compare the efficacy of oxitard and aloe vera in the management of OSMF.
Material and Methods: 120 subjects with OSMF were included in the study. The patients were clinico-pathologically diagnosed and divided equally in 2 groups, Group A (oxitard group) and Group B (aloe vera group). Group A was administered 2 oxitard capsules twice daily and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Different clinical parameters were evaluated at regular intervals. Data was analyzed using the Student’s paired t test and Chi-square test. P-value <0.001 was considered to be statistically significant.
Results: Clinical improvements in mouth opening and tongue protrusion was significant in the oxitard group (p=0.0005). Subjective symptoms of pain associated with the lesion (p=0.0003), difficulty in swallowing (p=0.0000) and speech (p=0.0001) also significantly improved in the Group A. The improvement in burning sensation was not statistically significant between the 2 groups (p=0.002). There was a mild to moderate decrease in the size of the lesion.
Conclusions: Though there is no definitive treatment for the condition however, overall assessment of symptoms like mouth opening, tongue protrusion, difficulty in swallowing and speech and pain associated with the lesion showed that oxitard capsules can bring about significant clinical improvements than aloe vera gel in the treatment of OSMF.
</p><p><bold> Key words:</bold>Oral submucous fibrosis, oxitard capsules, aloe vera, burning sensation, mouth opening.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cox, Sc" uniqKey="Cox S">SC Cox</name></author><author><name sortKey="Walker, Dm" uniqKey="Walker D">DM Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kale, Ad" uniqKey="Kale A">AD Kale</name></author><author><name sortKey="Mane, Dr" uniqKey="Mane D">DR Mane</name></author><author><name sortKey="Shukla, D" uniqKey="Shukla D">D Shukla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pindborg, Jj" uniqKey="Pindborg J">JJ Pindborg</name></author><author><name sortKey="Sirsat, Sm" uniqKey="Sirsat S">SM Sirsat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, Xc" uniqKey="Cox X">XC Cox</name></author><author><name sortKey="Walker, Dm" uniqKey="Walker D">DM Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramadass, T" uniqKey="Ramadass T">T Ramadass</name></author><author><name sortKey="Manokaran, G" uniqKey="Manokaran G">G Manokaran</name></author><author><name sortKey="Pushpala, Sm" uniqKey="Pushpala S">SM Pushpala</name></author><author><name sortKey="Narayanan, N" uniqKey="Narayanan N">N Narayanan</name></author><author><name sortKey="Kulkarni, Gn" uniqKey="Kulkarni G">GN Kulkarni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Bp" uniqKey="Singh B">BP Singh</name></author><author><name sortKey="Mittal, N" uniqKey="Mittal N">N Mittal</name></author><author><name sortKey="Sharma, V" uniqKey="Sharma V">V Sharma</name></author><author><name sortKey="Palani" uniqKey="Palani">Palani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rajendran, R" uniqKey="Rajendran R">R Rajendran</name></author><author><name sortKey="Rani, V" uniqKey="Rani V">V Rani</name></author><author><name sortKey="Shaikh, S" uniqKey="Shaikh S">S Shaikh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, S" uniqKey="Khan S">S Khan</name></author><author><name sortKey="Chatra, L" uniqKey="Chatra L">L Chatra</name></author><author><name sortKey="Prashanth, Sk" uniqKey="Prashanth S">SK Prashanth</name></author><author><name sortKey="Veena, Km" uniqKey="Veena K">KM Veena</name></author><author><name sortKey="Rao, Pk" uniqKey="Rao P">PK Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoithapprabhunath, Tr" uniqKey="Yoithapprabhunath T">TR Yoithapprabhunath</name></author><author><name sortKey="Maheswaran, T" uniqKey="Maheswaran T">T Maheswaran</name></author><author><name sortKey="Dineshshankar, J" uniqKey="Dineshshankar J">J Dineshshankar</name></author><author><name sortKey="Anusushanth, A" uniqKey="Anusushanth A">A Anusushanth</name></author><author><name sortKey="Sindhuja, P" uniqKey="Sindhuja P">P Sindhuja</name></author><author><name sortKey="Sitra, G" uniqKey="Sitra G">G Sitra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canniff, Jp" uniqKey="Canniff J">JP Canniff</name></author><author><name sortKey="Harvey, W" uniqKey="Harvey W">W Harvey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="More, Cb" uniqKey="More C">CB More</name></author><author><name sortKey="Das, S" uniqKey="Das S">S Das</name></author><author><name sortKey="Patel, H" uniqKey="Patel H">H Patel</name></author><author><name sortKey="Adalja, C" uniqKey="Adalja C">C Adalja</name></author><author><name sortKey="Kamatchi, V" uniqKey="Kamatchi V">V Kamatchi</name></author><author><name sortKey="Venkatesh, R" uniqKey="Venkatesh R">R Venkatesh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tilakaratne, Wm" uniqKey="Tilakaratne W">WM 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sortKey="Johnson, Nw" uniqKey="Johnson N">NW Johnson</name></author><author><name sortKey="Sankaranarayanan, R" uniqKey="Sankaranarayanan R">R Sankaranarayanan</name></author><author><name sortKey="Warnakulasuriya, S" uniqKey="Warnakulasuriya S">S Warnakulasuriya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borle, Rm" uniqKey="Borle R">RM Borle</name></author><author><name sortKey="Borle, Sr" uniqKey="Borle S">SR Borle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karemore, Tv" uniqKey="Karemore T">TV Karemore</name></author><author><name sortKey="Motwani, M" uniqKey="Motwani M">M Motwani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sudarshan, R" uniqKey="Sudarshan R">R Sudarshan</name></author><author><name sortKey="Annigeri, Rg" uniqKey="Annigeri R">RG Annigeri</name></author><author><name sortKey="Sree Vijayabala, G" uniqKey="Sree Vijayabala G">G Sree 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Exp Dent</journal-id><journal-id journal-id-type="iso-abbrev">J Clin Exp Dent</journal-id><journal-id journal-id-type="publisher-id">Medicina Oral S.L.</journal-id><journal-title-group><journal-title>Journal of Clinical and Experimental Dentistry</journal-title></journal-title-group><issn pub-type="epub">1989-5488</issn><publisher><publisher-name>Medicina Oral S.L.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25136428</article-id><article-id pub-id-type="pmc">4134856</article-id><article-id pub-id-type="publisher-id">51424</article-id><article-id pub-id-type="doi">10.4317/jced.51424</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject><subj-group><subject>Oral Medicine and Pathology</subject></subj-group></subj-group></article-categories><title-group><article-title>Comparative study of the efficacy of herbal antioxdants oxitard and aloe vera in the treatment of oral submucous fibrosis</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Patil</surname><given-names>Santosh</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Halgatti</surname><given-names>Vishal</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Maheshwari</surname><given-names>Sneha</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Santosh</surname><given-names>B S.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Reader, Dept of Oral Medicine and Radiology, Chattisgarh Dental College Research Institute, Rajnandgaon, Chattisgarh. India</aff><aff id="A2"><label>2</label>Assistant Professor, Dept of Dentistry, Belgaum Institute of Medical Sciences, Belgaum,Karnataka. India</aff><aff id="A3"><label>3</label>Dental Practitioner, Jodhpur, Rajasthan, India</aff><aff id="A4"><label>4</label>Reader, Dept of Oral and Maxillofacial Surgery, Chattisgarh Dental College Research Institute, Rajnandgaon, Chattisgarh. India</aff><author-notes><corresp> Dept of Oral Medicine and Radiology
Chattisgarh Dental College Research Institute
Rajnandgaon, 491441 (Chattisgarh). India
, E-mail: <email>drpsantosh@gmail.com</email></corresp><fn id="FN1" fn-type="conflict"><p><bold>Conflict of interest statement:</bold> As far as the authors are aware there was no conflict of interests.</p></fn></author-notes><pub-date pub-type="epub"><day>1</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="collection"><month>7</month><year>2014</year></pub-date><volume>6</volume><issue>3</issue><fpage>e265</fpage><lpage>e270</lpage><history><date date-type="accepted"><day>4</day><month>3</month><year>2014</year></date><date date-type="received"><day>1</day><month>1</month><year>2013</year></date></history><permissions><copyright-statement>Copyright: © 2014 Medicina Oral S.L.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder predominantly seen in the Indian subcontinent due to areca nut, tobacco and their products. The aim of the present study was to compare the efficacy of oxitard and aloe vera in the management of OSMF.
Material and Methods: 120 subjects with OSMF were included in the study. The patients were clinico-pathologically diagnosed and divided equally in 2 groups, Group A (oxitard group) and Group B (aloe vera group). Group A was administered 2 oxitard capsules twice daily and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Different clinical parameters were evaluated at regular intervals. Data was analyzed using the Student’s paired t test and Chi-square test. P-value <0.001 was considered to be statistically significant.
Results: Clinical improvements in mouth opening and tongue protrusion was significant in the oxitard group (p=0.0005). Subjective symptoms of pain associated with the lesion (p=0.0003), difficulty in swallowing (p=0.0000) and speech (p=0.0001) also significantly improved in the Group A. The improvement in burning sensation was not statistically significant between the 2 groups (p=0.002). There was a mild to moderate decrease in the size of the lesion.
Conclusions: Though there is no definitive treatment for the condition however, overall assessment of symptoms like mouth opening, tongue protrusion, difficulty in swallowing and speech and pain associated with the lesion showed that oxitard capsules can bring about significant clinical improvements than aloe vera gel in the treatment of OSMF.
</p><p><bold> Key words:</bold>Oral submucous fibrosis, oxitard capsules, aloe vera, burning sensation, mouth opening.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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